The Center for the Biology of Chronic Disease

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Marschall S. Runge, MD, PhD

Marion Covington Distinguished Chair, Chairman of the Department of Medicine, University of North Carolina

COMMENTS

This text formulates an interesting hypothesis, potentially linking a number of chronic diseases through a common mechanism. Dr. Polansky has brought together threads from a number of high profile, disease-specific areas of
investigation in a manner that is of interest to a broad group of scientists. The detailed consideration of topics ranging from cytokine activation to intracellular signaling to lipid metabolism is impressive. Although well written, the text is not for the timid or the novice. It will, however be very useful for scientists considering broad, comprehensive funding initiatives, and may be of interest to seminar groups studying disease origins. Overall, for scientists who can think "outside the box," this is a fascinating series of thoughts on the origin of chronic diseases.

BIOGRAPHY

Marschall S. Runge, MD, PhD is the Marion Covington Distinguished Chair and Chairman of the Department of Medicine at the University of North Carolina. He obtained his PhD in Molecular Biology from Vanderbilt University and his MD from Johns Hopkins University. He completed his medical residency at the Johns Hopkins Hospital and his cardiology fellowship training at the Massachusetts General Hospital. At the MGH, Dr. Runge trained with Edgar Haber, beginning what was a long-term collaboration on the role of thrombosis in vascular biology. When Dr. Haber left to become President of Bristol-Myers Squibb, Dr. Runge joined the faculty at Emory University as an Associate Professor. There he became interested in reactive oxygen species and their role in vascular pathology and atherosclerosis. He was recruited from Emory to the University of Texas Medical Branch in Galveston as Chief of Cardiology and Director of the Sealy Center for Molecular Cardiology. Then he was recruited by UNC in 2000. Dr. Runge has been continuously funded by the NHLBI since his fellowship at the MGH. He served as a member of the Experimental Cardiovascular Sciences Study Section of the NIH for five years, the last year (2002-2003) as Chair of the Study Section. He has published over 150 peer-reviewed manuscripts in the areas described above and is a renowned leader in vascular biology. He is also an editor of two clinical texts: Netter's Internal Medicine and Netter's Cardiology (to be published in 2004) and two upcoming basic science texts: the Principles of Molecular Cardiology and the Principles of Molecular Medicine (Second Edition).

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