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The Center for the Biology of Chronic Disease

HPV Treatments

Background

What is Cervical Dysplasia or CIN?

Cervical Dysplasia: Also known as Cervical Interstitial Neoplasia or Cervical Intraepithelial Neoplasia (CIN). This is a premalignant transformation or abnormal growth on the surface of the cervix. It is not cancer. In most cases the abnormal growth remains stable, and even eliminated by the immune system. However, in some cases, if left untreated, it progresses into cervical cancer. Therefore, most doctors recommend to surgically remove the abnormal growth (see more below).

There are three grades of CIN.
CIN 1: Marks low risk, mild dysplasia, or abnormal cell growth. It is found in the the basal 1/3 of the epithelium. In most cases it is cleared by immune system in about a year, but it can also take a few years.
CIN 2: Marks medium risk, or moderate dysplasia. It is found in the basal 2/3 of the epithelium.
CIN 3: Marks severe dysplasia. It is found in more than 2/3 of the epithelium. Sometimes it is found in the full thickness of the epithelium. This growth is also called cervical carcinoma in situ.

The cause of these abnormal growths is the human papillomavirus (HPV). Most of the times, it is caused by the high-risk HPV type 16 and HPV type 18.

What is HPV?

WebMD says "HPV stands for human papillomavirus, but there are actually more than 100 related viruses in this group. Each HPV virus is given a number or type. The term 'papilloma' refers to a kind of wart that results from some HPV types.

HPV lives in the body's epithelial cells. These are flat and thin cells found on the skin's surface and also on the surface of the vagina, anus, vulva, cervix, penis head, mouth, and throat.

Of the 100 HPV types, about 60 types cause warts on areas such as the hands or feet. The other 40 or so types of HPV are sexually transmitted and are drawn to the body's mucous membranes, such as the moist layers around the anal and genital areas." (1)

How Do You Get HPV?

The CDC says that "HPV is passed on through genital contact, most often during vaginal and anal sex. HPV may also be passed on during oral sex and genital-to-genital contact. HPV can be passed on between straight and same-sex partners - even when the infected partner has no signs or symptoms.

A person can have HPV even if years have passed since he or she had sexual contact with an infected person. Most infected persons do not realize they are infected or that they are passing the virus on to a sex partner. It is also possible to get more than one type of HPV.

Very rarely, a pregnant woman with genital HPV can pass HPV to her baby during delivery. In these cases, the child can develop recurrent respiratory papillomatosis (RRP), a rare condition in which warts grow in the throat. In children, this is also referred to as juvenile-onset recurrent respiratory papillomatosis (JORRP)." (2)

"About 20 million people in the U.S. are infected with HPV at any time, according to the CDC. And three-fourths of sexually active people between ages 15 and 49 have been infected at some point in their lives, according to estimates from the American Social Health Association.

You're more likely to get HPV if you:

  • Have sex at an early age

  • Have many sex partners

  • Have a sex partner who has had multiple partners" (1)

How Do You Prevent an HPV Infection?

"The only way to absolutely avoid the risk of HPV infection is to abstain from sex. You can also limit the number of sexual partners you have. And you can choose partners who've had few or no sexual partners before you. However, while a long-term monogamous relationship lowers your risk, it's important to remember that many people are infected and never know it." (1)

How Treat HPV?

Surgical Procedures

There are no drugs approved for curing an infection with the HPV virus. However, doctors may prescribe a surgical procedure, such as cryotherapy, conization, and the Loop Electrosurgical Excision Procedure (LEEP) to remove HPV warts.

In general, these procedures use liquid nitrogen, a surgical knife (scalpel), a carbon dioxide (CO2) laser, or electrical current to remove the cells that harbor the active viruses, that is, those viruses that reside in the warts and cause them to grow. These procedures only remove the visible symptoms of the HPV infection, that is, the skin or genital warts. They don't target the invisible infection, that is, the cells with the latent viruses. These viruses are left untouched. Since they only remove the active viruses, they produce a temporary remission, not a cure. See more on the difference between remission and cure, here.

If you have visible genital warts, and would like to learn more about the procedures used to remove them, visit: WebMD: Genital Wart Removal.

Vaccines

Doctors and health officials may recommend vaccination with Gardasil (developed by Merck Pharmaceuticals) or Cervarix (developed by GlaxoSmithKline).  These vaccines aim to prevent a future HPV infection. These vaccines do not treat cancer, genital warts, or any other symptom of an HPV infection, and they do not help individuals who are already infected.

See more about Gardasil, here.

Natural Remedies

Many doctors may also prescribe a natural product that was shown to work in published clinical studies. (3) One such natural product is Gene-Eden-VIR. The unique feature of this product is that it targets the latent HPV.

The CBCD tested the safety and effectiveness of Gene-Eden-VIR in a post-marketing clinical study. The study showed that Gene-Eden-VIR decreases symptoms of the HPV virus (and other viruses). The study was published in the medical journal Pharmacology and Pharmacy, in a special edition called Advances in Antiviral Drugs

Although it is written in a language suitable for scientists, we urge you to read the full Gene-Eden-VIR clinical study, see frame below. You can also watch Dr. Hanan Polansky, one of the scientists who conducted the study, explains it.




There are two products on the market, Novirin and Gene-Eden-VIR, that have the same five natural ingredients: 100 mg of quercetin, 150 mg of green tea extract, 50 mg of a cinnamon extract, 25 mg of a licorice extract, and 100 mcg of selenium. The difference between the two products is that Novirin has higher quality, more expensive ingredients.

Click Novirin or Gene-Eden-VIR to read more information about these products.



In recent years, there has been an increase in the demand for natural remedies, and there is growing evidence that some of these products are safe and effective. Moreover, natural remedies are a viable option when no other treatments are available, such as for those already infected with the latent HPV, and for those wishing to avoid the risks associated with other treatments, and are willing to wait the extra time it takes for these remedies to work. 

See more about Gene-Eden-VIR, here.


References:
  1. http://www.webmd.com/sexual-conditions/hpv-genital-warts/hpv-virus-information-about-human-papillomavirus

  2. http://www.cdc.gov/std/hpv/stdfact-hpv.htm

  3. http://www.cbcd.net/Gene-Eden-VIR-Clinical-Study.php

John S. Boyd, Ph.D.
The Center for the Biology of Chronic Disease, or CBCD (see http://www.cbcd.net/) Rochester, NY

The CBCD is a 501(c)3 not-for-profit organization that specializes in researching the biology of chronic disease. "The biology of chronic disease" means the original disruption that causes the disease, and the sequence of events that lead from the original disruption to the development of clinical symptoms. The CBCD hopes that once the biology is clear, pharmaceutical and biotech companies will be able to formulate drugs that reverse the effects of the disruption, and therefore cure the disease, or even block the original disruption, and therefore prevent the disease from developing in healthy individuals.

The CBCD conducted the clinical study that tested the safety and effectiveness of Gene-Eden-VIR.

 


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