On behalf of all the people who suffer from a disease and desperately need a cure,
we would like thank the individuals and organizations who support and sponsor us.
If you want a cure for cancer, heart disease, or diabetes, you need to support the CBCD.
Don't count on the National Institute of Health (NIH), or the biotech/pharmaceutical industry to do the job.
With all the money they spent on this problem, they have very little to show for it.
In 1971, during the State of the Union address, President Nixon declared the war on cancer proposing
"an intensive campaign to find a cure for cancer." Since 1971, Americans spent, through taxes,
donations, and private R&D, about $200 billion
in inflation-adjusted dollars. This money produced 1.56 million papers on cancer.
Yet, today we are no closer to a cure than we were in 1971.
Consider what Dr. Almog says in his paper:
Drug Industry in "depression" 1: "When the basic science/biology of disease
is not available, no new drugs come to market." With the billion of dollars spent by the NIH on basic science,
and the millions of papers published on the topic, the question is, "Why isn't the
basic science/biology of disease available? Individual discoveries in the biology of human disease are
cornerstone in new treatments. However, in drug discovery, these basic science/biology discoveries are seemingly unrelated dots.
To connect the dots you need a theory. The Blind Men and the Elephant is a famous story about six blind men encountering an elephant for the first time. Each man, seizing on the single feature of the animal, which he appeared to have touched first, and being incapable of seeing it whole, loudly maintained his limited opinion on the nature of the beast. The elephant was considered a wall, a spear, a snake, a tree, a fan or a rope, depending on whether the blind men had first grasped the creature's side, tusk, trunk, knee, ear or tail. The story epitomizes the problem of the reductionist approach in biology. A recent book Microcompetition with Foreign DNA and the Origin of Chronic Disease, by Hanan Polansky , presents an alternative. The book identifies the disruption that causes atherosclerosis,
cancer, obesity, osteoarthritis, type II diabetes, alopecia, type I diabetes, multiple sclerosis, asthma, lupus,
thyroiditis, inflammatory bowel disease, rheumatoid arthritis, psoriasis, atopic dermatitis, graft versus host disease,
and other chronic diseases, and describes the sequence of events that leads from the disruption to the molecular,
cellular, and clinical effects."
What are the implications of the NIH failure?
A decline in the number of new drugs introduced by pharmaceutical companies. Consider what professor Taylor says in his paper:
Fewer new drugs from the pharmaceutical industry2:
"In 2002 spending on medicines exceeded $400bn worldwide. Optimists in the pharmaceutical industry believe that
the global market for their products will go on expanding by around 10% a year, with the United States continuing to lead
towards higher per capita outlays. Expenditure on research by the pharmaceutical
industry is also increasing worldwide. It is now over $45bn a year --- twice the sum recorded at the start of the 1990s ---
and projected to rise to $55bn by 2005-6. Concerns are growing, however, about the productivity of research
being funded by the major pharmaceutical companies. ... Empirical evidence indicates a
crisis in productivity in pharmaceutical research. The number of medicines
introduced worldwide that contain new active ingredients dropped from an average of over 60 a year in the late
1980s to 52 in 1991 and only 31 in 2001. The overall number of new active substances undergoing regulatory
review is still falling."
On the one hand, the expenditure on research is increasing. On the other, the number of new drugs is decreasing.
The professionals call this situation the
in drug discovery.
The NIH failed to produce the so much needed biology of chronic disease because it is caught in the reductionist mentality.
We offer an alternative to the reductionist approach. Support the alternative. Spread your bets. As Tom Cruise said in
Jerry Maguire: "Help me, help you."
Spread the word
Tell your friends and colleagues about our center, its mission, and discoveries. Link our website to your website.
We have good news. Share the good news with others.
1. Almog, D. Drug industry in "Depression". Med Sci Monit. 2005 Jan;11(1):SR1-4.
(We strongly recommend this paper. It presents a unique
description of the relationship between academic research and commercial drug discovery.)
2. Taylor D. Fewer New Drugs from the Pharmaceutical Industry. BMJ. 2003 Feb 22;326(7386):408-9.